Dr. Angie Serrano has been awarded a 2 year AHA Postdoctoral Grant for the project “The roles of Kmt2d in vasculogenesis.” – July 2018 – June 2020 https://professional.heart.org/idc/groups/ahamah-public/@wcm/@sop/@rsch/documents/downloadable/ucm_432213.pdf
Inhibition of Notch signaling rescues cardiovascular development in Kabuki Syndrome Kabuki Syndrome patients have a spectrum of congenital disorders, including congenital heart defects, the primary determinant of mortality. Seventy percent of Kabuki Syndrome patients have mutations in the histone methyl-transferase KMT2D. However, the underlying mechanisms that drive these congenital disorders are unknown. Here, we generated…
Trisheena, a former NARI (Native American Research Internship – University of Utah) student in the Yost lab, who trained with Angie Serrano summer 2018 is being honoured for her academic excellence and dedication to her family and Crow culture at Montana State University’s 2019 American Indian Council Powwow. Congratulations Trisheena! Read the article from Montana…
Here, we show that neural crest derived cardiomyocytes (NC-Cms) in the zebrafish ventricle express Notch ligand jag2b, are adjacent to Notch responding cells, and persist throughout life. Genetic ablation of NC-Cms during embryogenesis results in diminished jag2b, altered Notch signaling and aberrant trabeculation patterns, but is not detrimental to early heart function or survival to adulthood. However,…
Neurobiology & Anatomy Department News highlights recent Yost lab paper https://medicine.utah.edu/neurobiology-anatomy/news/2018/11/yost-nature-communications-paper.php
Angie Serrano has uploaded her preprint https://www.biorxiv.org/content/10.1101/489757v1 Here we show a regulatory link between Notch pathway and Kmt2d during vasculogenesis. Pharmacological inhibition of Notch signaling rescues cardiovascular phenotype in zebrafish Kabuki Syndrome.
