Angie’s paper published in PLoS Biology
Inhibition of Notch signaling rescues cardiovascular development in Kabuki Syndrome Kabuki Syndrome patients have a spectrum of congenital disorders, including congenital heart defects, the primary determinant of mortality. Seventy percent of Kabuki Syndrome patients have mutations in the histone methyl-transferase KMT2D. However, the underlying mechanisms that drive these congenital disorders are unknown. Here, we generated…
