Sarah’s postdoc work published in Nature Communications!

Here, we show that neural crest derived cardiomyocytes (NC-Cms) in the zebrafish ventricle express Notch ligand jag2b, are adjacent to Notch responding cells, and persist throughout life. Genetic ablation of NC-Cms during embryogenesis results in diminished jag2b, altered Notch signaling and aberrant trabeculation patterns, but is not detrimental to early heart function or survival to adulthood. However,…

New preprint in BioRxiv!

Angie Serrano has uploaded her preprint Here we show a regulatory link between Notch pathway and Kmt2d during vasculogenesis. Pharmacological inhibition of Notch signaling rescues cardiovascular phenotype in zebrafish Kabuki Syndrome.